#13#
Revisiones-Ciencias
Básicas-Microorganismos *** Reviews-Basic Sciences-Microorganisms
INMUNOSUPRESIÓN
*** IMMUNOSUPPRESSION
(Conceptos
/ Keywords: Immunosuppression; Immunosuppressive ag.; Transpl. immunol.; GVH;
Antirejection therapy; Lymphocyte depletion; Transpl. conditioning; etc).
Enero /
January 2001 --- Marzo / March 2004
La
biblioteca del conocimiento biomédico© es un servicio GRATUITO. Toda la
información ha sido obtenida de fuentes públicas, de portales de internet que
no requieren registro alguno para su uso, que no requieren estar de acuerdo con
sus Términos de uso, que son de libre acceso a todo el mundo, y son a su vez
gratuitos. La biblioteca (revisiones, guías, protocolos, medicina basada en la evidencia,
etc...) se recopila en base a una patente que permite a Effiloop la
catalogación de los artículos por campos de interés así como por el orden de su
importancia (se proveen las primeras 200 revisiones). Toda la informacion se
ampara en las leyes de libre pensamiento-expresión, y de uso justo. Este
documento sólo contiene artículos escritos en Castellano y/o Inglés.
The
biomedical library© is a FREE service. All the information has been obtained
from public sources, from web sites that do not require registration for their
use, that do not require an agreement with their Terms of use, that provide
free access for all, and are free of charge. The library (reviews, guides,
protocols, medicine based medicine, etc) is arranged according to a patent that
warrants Effiloop to catalogue the articles by fields of interest as well as to
sort articles by true relevance (the first 200 reviews are provided). All the
information is provided according to the freedom of speech and fair use laws.
Only articles written in Spanish and/or English are included.
[1]
TÍTULO / TITLE: - Immunopathogenesis and
immunotherapy in AIDS virus infections.
REVISTA
/ JOURNAL: - Nat Med 2003 Jul;9(7):861-6.
●●
Enlace al texto completo (gratuito o de pago) 1038/nm0703-861
AUTORES
/ AUTHORS: - Letvin NL; Walker BD
INSTITUCIÓN
/ INSTITUTION: - Division of Viral Pathogenesis, Beth
Israel Deaconess Medical Center, Massachusetts General Hospital, Harvard
Medical School, Boston, Massachusetts 02114, USA.
RESUMEN
/ SUMMARY: - The heterogeneity of HIV and the different
human leukocyte antigen (HLA) backgrounds of infected individuals have posed
challenges to understanding the pathogenesis of HIV infection. But continuing
advances in our knowledge of the role of immune responses in controlling HIV
viremia should help to define goals for immune-based therapies and vaccine
strategies against AIDS. N.
Ref:: 106
----------------------------------------------------
[2]
TÍTULO / TITLE: - Defying death—HIV
mutation to evade cytotoxic T lymphocytes.
REVISTA
/ JOURNAL: - N Engl J Med. Acceso gratuito al texto
completo a partir de los 6 meses de la fecha de publicación.
●●
Enlace a la Editora de la Revista http://content.nejm.org/
●●
Cita: New England J Medicine (NEJM): <> 2002 Oct 10;347(15):1203-4.
●●
Enlace al texto completo (gratuito o de pago) 1056/NEJMcibr022067
AUTORES
/ AUTHORS: - Lieberman J
INSTITUCIÓN
/ INSTITUTION: - Center for Blood Research, Boston, MA
02115, USA. N. Ref:: 5
----------------------------------------------------
[3]
TÍTULO / TITLE: - Effects of MHC class I
on HIV/SIV disease in primates.
REVISTA
/ JOURNAL: - AIDS 2002;16 Suppl 4:S105-14.
AUTORES
/ AUTHORS: - Carrington M; Bontrop RE
INSTITUCIÓN
/ INSTITUTION: - Basic Research Program, SAIC Frederick,
National Cancer Institute, Frederick, MD 21702, USA. carringt@ncifcrf.gov
RESUMEN
/ SUMMARY: - Data indicate that resistance to HIV-1
disease involves an array of contrasting HLA genotypic effects that are subtle,
but significant, particularly when these genetic effects are considered as a
whole. Numerous reports attributing a role for HLA genotype in AIDS outcomes
have been reported, and a few of these have been affirmed in multiple studies.
Functional studies of immune cell recognition have provided clues to the
underlying mechanisms behind some of the strongest HLA associations, suggesting
the means by which relative resistance or susceptibility to the virus may
occur. SIV infection in non-human primates has served as an invaluable model
for understanding AIDS pathogenesis (in rhesus monkeys) and viral resistance
(in chimpanzee). The effect of rhesus MHC class I molecules on the evolution of
SIV has been convincingly described [19], and a recent study in humans has
suggested that selection pressure conferred by HLA molecules is responsible for
specific genetic variation in HIV-1 [114]. HIV-1 may eventually have
conspicuous evolutionary effects on HLA and other AIDS restriction genes, a
prolonged process that could have occurred in chimpanzee [92].To prevent such
an outcome, it will be necessary to approach the disease from many
perspectives, andapply comprehensively the knowledge gained to the successful
control of the virus. N.
Ref:: 114
----------------------------------------------------
[4]
TÍTULO / TITLE: - Virus evasion of MHC
class I molecule presentation.
REVISTA
/ JOURNAL: - J Immunol. Acceso gratuito al texto
completo a partir de 1 año de la fecha de publicación.
●●
Enlace a la Editora de la Revista http://www.jimmunol.org/
●●
Cita: J. of Immunology: <> 2003 Nov 1;171(9):4473-8.
AUTORES
/ AUTHORS: - Petersen JL; Morris CR; Solheim JC
INSTITUCIÓN
/ INSTITUTION: - Eppley Institute for Research in Cancer
and Allied Diseases, Omaha, NE 68198-6805, USA. N. Ref:: 97
----------------------------------------------------
[5]
TÍTULO / TITLE: - Fatal Scopulariopsis
brevicaulis infection in a paediatric stem-cell transplant patient treated with
voriconazole and caspofungin and a review of Scopulariopsis infections in
immunocompromised patients.
REVISTA
/ JOURNAL: - J Infect 2004 Jan;48(1):112-6.
AUTORES
/ AUTHORS: - Steinbach WJ; Schell WA; Miller JL;
Perfect JR; Martin PL
INSTITUCIÓN
/ INSTITUTION: - Division of Pediatric Infectious Diseases,
Department of Pediatrics, Duke University Medical Center, Box 3499, Durham, NC,
USA. stein022@mc.duke.edu N. Ref:: 33
----------------------------------------------------
[6]
TÍTULO / TITLE: - Dendritic cells transduced
with viral interleukin 10 or Fas ligand: no evidence for induction of
allotolerance in vivo.
REVISTA
/ JOURNAL: - Transplantation 2002 Jan 15;73(1
Suppl):S27-30.
AUTORES
/ AUTHORS: - Buonocore S; Van Meirvenne S; Demoor FX;
Paulart F; Thielemans K; Goldman M; Flamand V
INSTITUCIÓN
/ INSTITUTION: - 2 Laboratory of Physiology, Medical School
of Vrije Universiteit Brussel.
RESUMEN
/ SUMMARY: - Dendritic cells (DC) are the most potent
presenters of alloantigens and therefore are responsible for the induction of
allograft rejection. Genetic modifications of DC allowing the expression of a
tolerogenic molecule may render them immunosuppressive. We transduced bone
marrow-derived DC with recombinant MFG retrovirus encoding either viral
interleukin (vIL)-10 or Fas ligand (FasL) to induce transplantation tolerance.
Up to 10 ng/ml of bioactive vIL-10 was produced by DC after transfer of the
corresponding gene. Although the inhibitory properties of vIL-10-transduced DC
were revealed in vitro in a mixed lymphocyte culture, no clear down-regulation
of the allogeneic response was observed in vivo after single or multiple
injections of those DC overexpressing vIL-10. When we transduced wild-type bone
marrow-derived DC with recombinant MFG retrovirus encoding murine FasL, cells
quickly died, probably because of suicidal or fratricidal Fas-dependent death.
Indeed, only DC from Fas-deficient lpr mice survived to FasL gene transfer.
Those FasL-transduced lpr DC exhibited a strong cytotoxic activity against
Fas-positive targets in vitro. DC overexpressing FasL did not behave as
immunosuppressive DC in vivo. The subcutaneous injection of FasL+ lpr DC in MHC
class II-disparate mice hyperactivated the allospecific proliferation of T
cells in the draining lymph nodes compared with mice treated with
control-transduced DC. These results argue against the development of FasL+ DC
or vIL-10-secreting DC as immunosuppressive tools in vivo. The alternative
pathways of T-cell activation triggered by these genetically modified DC need
to be investigated. N.
Ref:: 20
----------------------------------------------------
[7]
TÍTULO / TITLE: - Penicillin-resistant
Streptococcus pneumoniae septic shock and meningitis complicating chronic graft
versus host disease: a case report and review of the literature.
REVISTA
/ JOURNAL: - Am J Med 2002 Aug 1;113(2):152-5.
AUTORES
/ AUTHORS: - Haddad PA; Repka TL; Weisdorf DJ
INSTITUCIÓN
/ INSTITUTION: - Division of Hematology, Oncology and
Transplantation, Department of Medicine, University of Minnesota, Minneapolis,
USA. N. Ref:: 34
----------------------------------------------------
[8]
TÍTULO / TITLE: - Cross-presentation in
viral immunity and self-tolerance.
REVISTA
/ JOURNAL: - Nat Rev Immunol 2001 Nov;1(2):126-34.
●●
Enlace al texto completo (gratuito o de pago) 1038/35100512
AUTORES
/ AUTHORS: - Heath WR; Carbone FR
INSTITUCIÓN
/ INSTITUTION: - Immunology Division, The Walter and Eliza
Hall Institute, Melbourne Hospital, Parkville, Victoria, Australia. heath@wehi.edu.au
RESUMEN
/ SUMMARY: - T lymphocytes recognize peptide antigens
presented by class I and class II molecules encoded by the major
histocompatibility complex (MHC). Classical antigen-presentation studies showed
that MHC class I molecules present peptides derived from proteins synthesized
within the cell, whereas MHC class II molecules present exogenous proteins
captured from the environment. Emerging evidence indicates, however, that
dendritic cells have a specialized capacity to process exogenous antigens into
the MHC class I pathway. This function, known as cross-presentation, provides
the immune system with an important mechanism for generating immunity to viruses
and tolerance to self. N.
Ref:: 83
----------------------------------------------------
[9]
TÍTULO / TITLE: - Scedosporium
prolificans osteomyelitis in an immunocompetent child treated with voriconazole
and caspofungin, as well as locally applied polyhexamethylene biguanide.
REVISTA
/ JOURNAL: - J Clin Microbiol. Acceso gratuito al texto
completo a partir de los 6 meses de la fecha de publicación.
●●
Enlace a la Editora de la Revista http://jcm.asm.org/
●●
Cita: J. Clinical Microbiology: <> 2003 Aug;41(8):3981-5.
AUTORES
/ AUTHORS: - Steinbach WJ; Schell WA; Miller JL;
Perfect JR
INSTITUCIÓN
/ INSTITUTION: - Department of Pediatrics, Duke University,
Durham, North Carolina 27710, USA. stein022@mc.duke.edu
RESUMEN
/ SUMMARY: - Scedosporium species are increasingly
isolated from immunocompromised and immunocompetent patients. Unfortunately,
Scedosporium infections are generally resistant to amphotericin B, and Scedosporium
prolificans strains are particularly resistant to the antifungal agents now in
use. We report here on an immunocompetent child with S. prolificans-associated
osteomyelitis successfully treated with debridement, local irrigation with
polyhexamethylene biguanide, and the systemic administration of voriconazole
and caspofungin despite poor in vitro activity of voriconazole alone against
the isolate. We also review the treatments and outcomes of 28 reported cases of
osteomyelitis or septic arthritis caused by Scedosporium species in
immunocompetent patients. N.
Ref:: 62
----------------------------------------------------
[10]
TÍTULO / TITLE: - Therapeutic management
of extrahepatic manifestations in patients with chronic hepatitis C virus
infection.
REVISTA
/ JOURNAL: - Rheumatology (Oxford). Acceso gratuito al
texto completo a partir de los 2 años de la fecha de publicación.
●●
Enlace a la Editora de la Revista http://rheumatology.oupjournals.org/
●●
Cita: Rheumatology (Oxford): <> 2003 Jul;42(7):818-28. Epub 2003 Apr 16.
●●
Enlace al texto completo (gratuito o de pago) 1093/rheumatology/keg299
AUTORES
/ AUTHORS: - Ramos-Casals M; Trejo O; Garcia-Carrasco
M; Font J
INSTITUCIÓN
/ INSTITUTION: - Department of Autoimmune Diseases,
Clinical Institutes of Infection and Immunology, Insitut d’Investigacions
Biomediques August Pi i Sunyer, Hospital Clinic, Department of Medicine, School
of Medicine, University of Barcelona, España. mramos@clinic.ub.es N. Ref:: 123
----------------------------------------------------
[11]
TÍTULO / TITLE: - Clinical protocol.
Purging of autologous stem cell sources with bcl-x(s) adenovirus for women
undergoing high-dose chemotherapy for stage IV breast carcinoma.
REVISTA
/ JOURNAL: - Hum Gene Ther 2001 Nov 1;12(16):2023-5.
AUTORES
/ AUTHORS: - Ayash LJ; Clarke M; Adams P; Ferrara J;
Ratanatharathorn V; Reynolds C; Roessler B; Silver S; Strawderman M; Uberti J;
Wicha M
RESUMEN
/ SUMMARY: - High-dose chemotherapy (HDCT) and
autologous bone marrow transplantation (BMT) is frequently used to treat
patients with metastatic cancer including breast cancer and neuroblastoma.
However, the bone marrow of such patients is often contaminated with tumor
cells. Recently, we have found that a recombinant adenovirus vector that
contains a bcl-x, minigene (a dominant negative inhibitor of the bcl-2 family),
called the bcl-x(s) adenovirus, is lethal to cancer cells derived from
epithelial tissues, but not to normal human hematopoietic cells. To determine
the mechanism, by which this virus spares normal hematopoietic cells, we
isolated normal mouse hematopoietic stem cells and infected them with an
adenovirus that contains a beta-galactosidase minigene. Such cells do not
express beta-galactosidase, indicating that hematopoietic stem cells do not
express transgene encoded by adenovirus vectors based upon the RSV-AD5 vector
system. When breast cancer cells mixed with hematopoietic cells were infected
with the bcl-x(s) adenovirus, cancer cells were selectively killed by the
suicide adenoviruses. Hematopoietic cells exposed to the suicide vectors were
able to reconstitute the bone marrow of mice exposed to lethal doses of
y-irradiation. These studies suggest that adenovirus suicide vectors may
provide a simple and effective method to selectively eliminate cancer cells
derived from epithelial tissue that contaminate bone marrow to be used for
autologous BMT. We therefore propose to initiate a phase I clinical trial to
test the safety of this virus in women with breast cancer undergoing high does
chemotherapy and autologous BMT.
----------------------------------------------------
[12]
TÍTULO / TITLE: - Regulation of gene
expression in lymphocytes and antigen-presenting cells by measles virus:
consequences for immunomodulation.
REVISTA
/ JOURNAL: - J Mol Med 2002 Feb;80(2):73-85. Epub 2001
Nov 15.
●●
Enlace al texto completo (gratuito o de pago) 1007/s00109-001-0299-x
AUTORES
/ AUTHORS: - Schneider-Schaulies S; Bieback K; Avota E;
Klagge I; ter Meulen V
INSTITUCIÓN
/ INSTITUTION: - Institute for Virology and Immunobiology,
University of Wurzburg, Versbacher Strasse 7, 97078 Wurzburg, Germany. s-s-s@vim.uni-wuerzburg.de
RESUMEN
/ SUMMARY: - Acute measles, a well known disease
usually contracted during early childhood, is still the major cause of
vaccine-preventable infant deaths worldwide. There are about 40 million cases
of acute measles per year, with more than one million cases of infant death as
a consequence of measles. These are mainly due to opportunistic infections which
develop on the basis of a generalized suppression of the cellular immunity in
the course and after the acute disease. Lymphopenia, a general proliferative
unresponsiveness of T cells ex vivo and cytokine imbalance, are considered as
major hallmarks of measles virus (MV) induced immunosuppression. These findings
are compatible with modulation of T cell responses by viral interference with
professional antigen-presenting cells such as dendritic cells or direct effects
on T cells by suppression of survival or proliferation signals. In vitro, MV
interaction causes a variety of effects on dendritic cells, including
maturation and loss of their allostimulatory functions. Whether there is an
additional impact on the quality of T cell responses is unknown as yet. It is
clear, however, that surface interaction of lymphocytes with the MV
glycoprotein complex is necessary and sufficient to induce a state of
proliferative unresponsiveness in T cells. This surface contact mediated signal
essentially interferes with the propagation of the interleukin 2 receptor
signal by blocking the activation of the protein kinase B, also called Akt
kinase, both in vitro and after experimental infection. N. Ref:: 122
----------------------------------------------------
[13]
TÍTULO / TITLE: - Severe Ehrlichia
chaffeensis infection in a lung transplant recipient: a review of ehrlichiosis
in the immunocompromised patient.
REVISTA
/ JOURNAL: - Emerg Infect Dis. Acceso gratuito al texto
completo.
●●
Enlace a la Editora de la Revista http://www.cdc.gov/
●●
Cita: Emerging Infectious Diseases: <> 2002 Mar;8(3):320-3.
AUTORES
/ AUTHORS: - Safdar N; Love RB; Maki DG
INSTITUCIÓN
/ INSTITUTION: - Section of Infectious Diseases, University
of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA.
RESUMEN
/ SUMMARY: - We describe a case of human ehrlichiosis
in a lung transplant recipient and review published reports on ehrlichiosis in
immunocompromised patients. Despite early therapy with doxycycline, our patient
had unusually severe illness with features of thrombotic thrombocytopenic
purpura. Of 23 reported cases of ehrlichiosis in immunocompromised patients,
organ failure occurred in all patients and 6 (25%) died. N. Ref:: 32
----------------------------------------------------
[14]
TÍTULO / TITLE: - Subcutaneous black
fungus (phaeohyphomycosis) infection in renal transplant recipients:three
cases.
REVISTA
/ JOURNAL: - Transplantation 2004 Jan 15;77(1):140-2.
●●
Enlace al texto completo (gratuito o de pago) 1097/01.TP.0000107287.70512.E7
AUTORES
/ AUTHORS: - Yehia M; Thomas M; Pilmore H; Van Der
Merwe W; Dittmer I
INSTITUCIÓN
/ INSTITUTION: - Auckland Renal Transplant Group, Auckland
Hospital, Auckland, New Zealand. mahay@adhb.govt.nz
RESUMEN
/ SUMMARY: - We describe three cases of subcutaneous
phaeohyphomycosis developing in the lower limbs of renal transplant recipients
shortly after transplantation. Each case presented with dark-colored nodules
that subsequently ulcerated. Histopathologic examination revealed dematiaceous
fungal hyphae with a surrounding granulomatous reaction. The fungi were
subsequently identified as Alternaria alternatum in two cases and Phialophora
richardsiae in one case. In one case, the lesions resolved during a prolonged
(6-month) course of itraconazole without the requirement for surgical excision.
In the other two cases, combined medical and surgical treatment resulted in
cure. A review of the literature on phaeohyphomycosis is presented. N. Ref:: 11
----------------------------------------------------
[15]
TÍTULO / TITLE: - Vascular thrombosis and
acute cytomegalovirus infection in immunocompetent patients: report of 2 cases
and literature review.
REVISTA
/ JOURNAL: - Clin Infect Dis 2003 Jun 1;36(11):E134-9.
Epub 2003 May 19.
AUTORES
/ AUTHORS: - Abgueguen P; Delbos V; Chennebault JM;
Payan C; Pichard E
INSTITUCIÓN
/ INSTITUTION: - Department of Infectious Diseases, Centre
Hospitalo-Universitaire, Angers, France. piabgueguen@chu-angers.fr
RESUMEN
/ SUMMARY: - Acute cytomegalovirus (CMV) infection in
immunocompetent patients is common worldwide, with seroprevalence rates of
40%-100%, depending on the country, socioeconomic conditions, and the patient’s
age. Infection is most often asymptomatic, but acute cytomegalovirus infection
is occasionally revealed by prolonged fever, cervical lymphadenitis, and
arthralgia, and it is more rarely revealed by pneumonia, myocarditis,
pericarditis, colitis, and hemolytic anemia. Here, we report 2 cases of acute
CMV infection in nonimmunocompromised adults that were complicated by venous
thrombosis with pulmonary embolism. We also review previously reported cases of
vascular thrombosis and discuss the propensity of CMV to induce vascular damage
with associated thrombosis. N.
Ref:: 55
----------------------------------------------------
[16]
TÍTULO / TITLE: - The fission yeast TOR
proteins and the rapamycin response: an unexpected tale.
REVISTA
/ JOURNAL: - Curr Top Microbiol Immunol 2004;279:85-95.
AUTORES
/ AUTHORS: - Weisman R
INSTITUCIÓN
/ INSTITUTION: - Department of Molecular Microbiology and
Biotechnology, Faculty of Life Sciences, Tel-Aviv University, 69978 Tel-Aviv,
Israel. ronitt@post.tau.ac.il
RESUMEN
/ SUMMARY: - The TOR proteins are known as key
regulators of cell growth in response to nutritional and mitogenic signals and
as targets for the immunosuppressive and anti-cancerous drug rapamycin. The
fission yeast Schizosaccharomyces pombe has two TOR homologues, tor1+ and
tor2+. Despite their structural similarity, these genes have distinct functions:
tor1+ is required under starvation, extreme temperatures, and osmotic or
oxidative stress conditions, whereas tor2+ is required under normal growth
conditions. Surprisingly, rapamycin does not seem to inhibit the S. pombe
TOR-related functions. Rapamycin specifically inhibits sexual development in S.
pombe, and this seems to stem from direct inhibition of the S. pombe FKBP12
homologue. Why S. pombe cells are resistant to rapamycin during the growth
phase is as yet unclear and awaits further analysis of the TOR-dependent
signaling pathways. N.
Ref:: 27
----------------------------------------------------
[17]
TÍTULO / TITLE: - Efficacy of
pneumococcal polysaccharide vaccine in immunocompetent adults: a meta-analysis
of randomized trials.
REVISTA
/ JOURNAL: - Vaccine 2001 Sep 14;19(32):4780-90.
AUTORES
/ AUTHORS: - Cornu C; Yzebe D; Leophonte P; Gaillat J;
Boissel JP; Cucherat M
INSTITUCIÓN
/ INSTITUTION: - Service of Clinical Pharmacology, EA643,
Lyon University Hospital, Faculte de Medicine RTH Laennec, BP 8071, 69376,
Cedex 08, Lyon, France. catherine.cornu@upcl.univ-lyon1.fr
RESUMEN
/ SUMMARY: - The use of pneumococcal polysaccharide
vaccine (PPV) is low in some countries, maybe because of doubts regarding its
efficacy. This meta-analysis aims at combining evidence from randomized trials
of PPV assessing its efficacy in preventing Streptococcus pneumoniae related
diseases in immunocompetent adults. In the fourteen trials totalling 48,837 patients
retrieved, PPV prevents definite pneumococcal pneumonia by 71%, presumptive
pneumococcal pneumonia by 40%, and mortality due to pneumonia by 32%, but not
all-cause pneumonia or death. No preventive effect was seen in the subgroup of
patients aged 55 years or more, possibly due to a lack of statistical power.
----------------------------------------------------
[18]
TÍTULO / TITLE: - Disseminated ochroconis
gallopavum infection in a renal transplant recipient: the first reported case
and a review of the literature.
REVISTA
/ JOURNAL: - Clin Nephrol 2003 Dec;60(6):415-23.
AUTORES
/ AUTHORS: - Wang TK; Chiu W; Chim S; Chan TM; Wong SS;
Ho PL
INSTITUCIÓN
/ INSTITUTION: - Centre of Infection, Department of
Microbiology, Queen Mary Hospital, University of Hong Kong, Hong Kong, SAR,
China.
RESUMEN
/ SUMMARY: - Ochroconis gallopavum is a potentially
fatal dematiaceous fungus causing opportunistic infections in immunocompromised
hosts. We report the first case of disseminated O. gallopavum infection in a 13-year-old
renal transplant recipient, which involved the brain, lung and spleen. He was
treated with amphotericin B, itraconazole and voriconazole, a new antifungal
agent first used to treat such an infection. Besides antifungal treatment, all
immunosuppressive agents were stopped and automated peritoneal dialysis was
resumed. The initial infection was under control with both clinical and
radiological improvements after treatment. However, the patient later acquired
Acremonium spp. peritonitis; he failed to respond to high-dose amphotericin B,
and finally succumbed. A total of 13 reported O. gallopavum human infections,
including the one described here, are reviewed. The most common site of
involvement is the brain and the crude mortality rate is up to 46%. As the
disease is potentially lethal in immunocompromised hosts, empirical antifungal
coverage should be considered in post-renal transplant recipients with
suspected brain abscess. Early biopsy of lesion for histopathological and
microbiological diagnosis would be essential in managing such cases. N. Ref:: 23
----------------------------------------------------
[19]
TÍTULO / TITLE: - The HCMV gene products
US2 and US11 target MHC class I molecules for degradation in the cytosol.
REVISTA
/ JOURNAL: - Curr Top Microbiol Immunol 2002;269:37-55.
AUTORES
/ AUTHORS: - van der Wal FJ; Kikkert M; Wiertz E
INSTITUCIÓN
/ INSTITUTION: - Department of Medical Microbiology, Leiden
University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
RESUMEN
/ SUMMARY: - Over millions of years of coevolution with
their hosts, viruses have developed highly effective strategies to elude the
host immune system. The degradation of major histocompatibility complex (MHC)
class I heavy chains by human cytomegalovirus (HCMV) is an example of this. Two
HCMV proteins, US2 and US11, target newly synthesized MHC class I heavy chains
for destruction via a pathway that involves ubiquitin-dependent retrograde
transport, or “dislocation”, of the heavy chains from the ER to the cytosol,
where the proteins are degraded by proteasomes. In this review, US2- and
US11-mediated degradation of MHC class I heavy chains is discussed in relation
to data concerning the degradation of other ER luminal proteins. A new, unified
model for translocon-facilitated dislocation and degradation of MHC class I
heavy chains is presented. N.
Ref:: 115
----------------------------------------------------
[20]
TÍTULO / TITLE: - Beta-herpesvirus
challenges in the transplant recipient.
REVISTA
/ JOURNAL: - J Infect Dis. Acceso gratuito al texto
completo a partir de los 2 años de la publicación; - http://www.journals.uchicago.edu/
●●
Cita: J. of Infectious Diseases: <> 2002 Oct 15;186 Suppl 1:S99-S109.
AUTORES
/ AUTHORS: - Ljungman P
INSTITUCIÓN
/ INSTITUTION: - Karolinska Institutet, SE-14186 Stockholm,
Sweden. per.ljungman@medhs.ki.se
RESUMEN
/ SUMMARY: - Cytomegalovirus (CMV) has major
consequences after allogeneic stem cell and solid organ transplantation. CMV
may cause significant morbidity and mortality, and monitoring to detect
reactivation to reduce disease or management of end organ disease is associated
with increased resource utilization. Two other members of the beta-herpesvirus
family, human herpesvirus (HHV) type 6 and HHV-7, are increasingly recognized
as important pathogens in transplant recipients, either by direct infection
(e.g., encephalitis, hepatitis, or pneumonitis) or via interaction with CMV. In
addition to direct effects of CMV infection, such indirect effects as an
increased risk for bacterial and fungal infections or impaired graft acceptance
and function are important research topics. Diagnosis and treatment of CMV
infection is currently more advanced than for HHV-6 and HHV-7. N. Ref:: 109
----------------------------------------------------
[21]
TÍTULO / TITLE: - Cellular engineering of
HSV-tk transduced, expanded T lymphocytes for graft-versus-host disease
management.
REVISTA
/ JOURNAL: - Acta Haematol 2003;110(2-3):121-31.
●●
Enlace al texto completo (gratuito o de pago) 1159/000072461
AUTORES
/ AUTHORS: - Burger SR; Kadidlo DM; Basso L; Bostrom N;
Orchard PJ
INSTITUCIÓN
/ INSTITUTION: - Advanced Cell and Gene Therapy, Chapel
Hill, NC 27516, USA. sburger@ac-gt.com
RESUMEN
/ SUMMARY: - Engineering donor T lymphocytes with
inducible ‘suicide genes’, such as herpes simplex virus thymidine kinase, has
potential to improve safety and efficacy in allogeneic transplantation by
facilitating management of graft-versus-host disease. Elective administration
of a relatively nontoxic pro-drug would induce in vivo negative selection of
engineered lymphocytes specifically, sparing other donor hematopoietic cells.
The engineered cells must retain immunologic function, and undergo negative
selection in response to clinically attainable plasma concentrations of
pro-drug. The cell engineering process itself, typically involving activation,
transduction, ex vivo expansion, and selection, must produce clinically useful
numbers of genetically modified cells at high purity. We discuss development of
a cellular engineering manufacturing process that yields transduced, expanded T
lymphocytes meeting these requirements.
N. Ref:: 37
----------------------------------------------------
[22]
TÍTULO / TITLE: - Host and viral genetics
and risk of cervical cancer: a review.
REVISTA
/ JOURNAL: - Virus Res 2002 Nov;89(2):229-40.
AUTORES
/ AUTHORS: - Hildesheim A; Wang SS
INSTITUCIÓN
/ INSTITUTION: - Division of Cancer Epidemiology and
Genetics, National Cancer Institute, 6120 Executive Blvd, Room 7062, EPS/MSC#
7234, Rockville, MD 20852, USA. hildesha@exchange.nih.gov
RESUMEN
/ SUMMARY: - Infection with human papillomaviruses
(HPV) is known to play a central role in the development of cervical cancer.
Both host and viral genetic factors have been postulated to be important
determinants of risk of HPV progression to neoplasia among infected
individuals. In this report, we review epidemiological studies that have
evaluated the role in cervical cancer pathogenesis of genetic variation in
human leukocyte antigen (HLA) genes and in the HPV genome itself. A protective
effect of HLA Class II DRB1*13/DBQ1*0603 alleles is the most consistent HLA
finding in the published literature. A consistent association between HPV16
non-European variants and risk of disease is also evident from published work.
These findings are discussed. Gaps in our understanding and future research
needs are also discussed. N.
Ref:: 90
----------------------------------------------------
[23]
TÍTULO / TITLE: - Successful management
of disseminated Nocardia transvalensis infection in a heart transplant
recipient after development of sulfonamide resistance: case report and review.
REVISTA
/ JOURNAL: - J Heart Lung Transplant 2003
Apr;22(4):492-7.
AUTORES
/ AUTHORS: - Lopez FA; Johnson F; Novosad DM; Beaman
BL; Holodniy M
INSTITUCIÓN
/ INSTITUTION: - Department of Medicine, Louisiana State
University Health Sciences Center, New Orleans, Louisiana, USA.
RESUMEN
/ SUMMARY: - Nocardia transvalensis is a rarely
reported cause of clinically significant disease, and, to our knowledge, has
not been reported previously as a cause of infection in the cardiac transplant
population. We report a case of N transvalensis new taxon-2 pulmonary infection
that disseminated to the brain and skin in a cardiac transplant recipient
despite adequate sulfonamide serum levels. Subsequent isolates were resistant
to sulfonamides, and molecular ribotyping of the primary and subsequent
isolates confirmed that these were the same N transvalensis new taxon-2 strain.
The taxonomic and diagnostic considerations, as well as the clinical
significance of anti-microbial-resistant nocardia, are reviewed and discussed
herein. N. Ref:: 37
----------------------------------------------------
[24]
TÍTULO / TITLE: - Acremonium strictum
pulmonary infection in a leukemic patient successfully treated with
posaconazole after failure of amphotericin B.
REVISTA
/ JOURNAL: - Eur J Clin Microbiol Infect Dis 2002
Nov;21(11):814-7. Epub 2002 Oct 31.
●●
Enlace al texto completo (gratuito o de pago) 1007/s10096-002-0828-8
AUTORES
/ AUTHORS: - Herbrecht R; Letscher-Bru V; Fohrer C;
Campos F; Natarajan-Ame S; Zamfir A; Waller J
INSTITUCIÓN
/ INSTITUTION: - Departement d’Hematologie et d’Oncologie,
Hopital de Hautepierre, Avenue Moliere, 67098 Strasbourg, France. raoul.herbrecht@chru-strasbourg.fr
RESUMEN
/ SUMMARY: - A severely neutropenic patient with
chronic lymphocytic leukemia developed a diffuse bilateral pulmonary infection
while receiving a therapeutic daily dosage of intravenous amphotericin B for
Candida glabrata esophagitis. Computed tomography of the chest showed numerous
lung nodules, ground glass areas and a pleural effusion. Biopsy of one nodule
demonstrated hyaline septate hyphae. Multiple sputum cultures grew Acremonium
strictum. Increasing the dose of amphotericin B and the addition of itraconazole
did not resolve the infection. Change of treatment to posaconazole given orally
at 200 mg four times/d resulted in progressive improvement leading finally to
cure after 24 weeks of therapy. Treatment with posaconazole was clinically and
biologically well tolerated. N.
Ref:: 15
----------------------------------------------------
[25]
TÍTULO / TITLE: - Prevention of
cytomegalovirus disease in recipients of solid-organ transplants.
REVISTA
/ JOURNAL: - Clin Infect Dis 2001 Feb 15;32(4):596-603.
Epub 2001 Feb 6.
AUTORES
/ AUTHORS: - Paya CV
INSTITUCIÓN
/ INSTITUTION: - Division of Infectious Diseases and
Transplant Center, Mayo Clinic, Rochester, MN 55905. USA. paya@mayo.edu
RESUMEN
/ SUMMARY: - The introduction and combination of
more-potent immunosuppressive regimens, and the increased transplantation of
organs into more severely ill patients, have again placed cytomegalovirus (CMV)
disease in the spotlight of posttransplantation complications. Both direct and associated
complications related to CMV need to be considered in understanding the
pathogenesis of CMV infection after solid-organ transplantation. New diagnostic
methods with higher sensitivity for the detection of CMV and the ability to
quantify CMV indicate that low levels of CMV replication are present in many
patients who don’t have clinical symptoms ascribed to CMV infection. How these
low levels of CMV replication impact the outcome of the transplanted graft
remains unknown. In addition, there needs to be further study regarding whether
only patients at high risk for developing CMV disease or, also, those with
clinically asymptomatic levels of CMV replication should be the target of
effective preventive regimens. This review summarizes our current knowledge of
the pathogenesis of CMV infection after solid-organ transplantation, and it
outlines different effective preventive regimens and approaches. N. Ref:: 47
----------------------------------------------------
[26]
TÍTULO / TITLE: - Common community
respiratory viruses in patients with cancer: more than just “common colds”.
REVISTA
/ JOURNAL: - Cancer 2003 May 15;97(10):2576-87.
●●
Enlace al texto completo (gratuito o de pago) 1002/cncr.11353
AUTORES
/ AUTHORS: - Hicks KL; Chemaly RF; Kontoyiannis DP
INSTITUCIÓN
/ INSTITUTION: - Department of Bone Marrow Transplantation,
The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030,
USA.
RESUMEN
/ SUMMARY: - Community respiratory viruses long have
been recognized as primary respiratory pathogens among infants and young
children. More recently, it has become clear that these viruses cause a
considerable disease burden throughout life. The consequences of repeated
infections are most evident in elderly and immunocompromised persons. Even in
otherwise healthy persons, reinfections often require medical attention but
generally are undiagnosed and unrecognized. These reinfections may spread from
healthy persons to those at highest risk. Control requires a multifaceted
approach combining vaccination, chemoprophylaxis, and aggressive early
antiviral treatment of high-risk individuals, as well as education of all
populations affected by these viruses. N.
Ref:: 90
----------------------------------------------------
[27]
TÍTULO / TITLE: - Immune control of HIV:
the obstacles of HLA and viral diversity.
REVISTA
/ JOURNAL: - Nat Immunol 2001 Jun;2(6):473-5.
●●
Enlace al texto completo (gratuito o de pago) 1038/88656
AUTORES
/ AUTHORS: - Walker BD; Korber BT
INSTITUCIÓN
/ INSTITUTION: - Partners AIDS Research Center, Massachusetts
General Hospital and Division of AIDS, Harvard Medical School, Boston, MA
02114, USA. bwalker@helix.mgh.harvard.edu N. Ref:: 27
----------------------------------------------------
[28]
TÍTULO / TITLE: - Cutaneous lymphoma
associated with Epstein-Barr virus infection in 2 patients treated with
methotrexate.
REVISTA
/ JOURNAL: - Mayo Clin Proc. Acceso gratuito al texto
completo.
●●
Enlace a la Editora de la Revista http://www.mayo.edu/proceedings/
●●
Cita: Mayo Clinic Proceedings: <> 2001 Aug;76(8):845-8.
AUTORES
/ AUTHORS: - Tournadre A; D’Incan M; Dubost JJ; Franck
F; Dechelotte P; Souteyrand P; Soubrier M
INSTITUCIÓN
/ INSTITUTION: - Department of Rheumatology, Hjpital
Gabriel Montpied, Clermont-Ferrand, France.
RESUMEN
/ SUMMARY: - Whether patients with rheumatoid arthritis
(RA) have an increased risk of developing non-Hodgkin lymphoma is
controversial, and opinions differ on the possible role of methotrexate in the
occurrence of lymphomas in patients with RA. We report 1 T-cell lymphoma and 1
B-cell lymphoma restricted to the skin associated with Epstein-Barr virus infection
that healed completely and spontaneously after discontinuation of methotrexate
in a man with RA and a woman with dermatomyositis. Cutaneous infiltrating cells
were infected by a replicative form of Epstein-Barr virus. After
discontinuation of methotrexate, the cutaneous lesions disappeared completely
in 15 days without recurrence. Discontinuation of methotrexate is necessary in
patients with RA or dermatomyositis who have a lymphoproliferative disorder,
and a follow-up period of several weeks should be observed before specific
therapy is initiated. N.
Ref:: 18
----------------------------------------------------
[29]
TÍTULO / TITLE: - Hepatitis C virus
infection and vasculitis: implications of antiviral and immunosuppressive
therapies.
REVISTA
/ JOURNAL: - Arthritis Rheum 2002 Mar;46(3):585-97.
●●
Enlace al texto completo (gratuito o de pago) 1002/art.10107 [pii
●●
Enlace al texto completo (gratuito o de pago) 1002/art.10107
AUTORES
/ AUTHORS: - Vassilopoulos D; Calabrese LH
INSTITUCIÓN
/ INSTITUTION: - Hippokration General Hospital, Athens
University, Athens, Greece. N.
Ref:: 92
----------------------------------------------------
[30]
TÍTULO / TITLE: - Retroviral proteins
that target the major histocompatibility complex class I.
REVISTA
/ JOURNAL: - Virus Res 2002 Sep;88(1-2):119-27.
AUTORES
/ AUTHORS: - Johnson JM; Franchini G
INSTITUCIÓN
/ INSTITUTION: - National Cancer Institute, Basic Research
Laboratory, 41/D804, Bethesda, MD 20892-5055, USA. johnsonjm@helix.nih.gov
RESUMEN / SUMMARY: - The human T-cell leukemia virus type 1 (HTLV-1)